How Does CBD Get Metabolized In The Body

CBD has gained a lot of popularity for its therapeutic health benefits. It is considered to be a natural health supplement for a variety of health conditions such as anxiety, muscle pain, depression, stress, epilepsy, and more. The extent to which you get the benefits depends on the way CBD gets metabolized in the body.

In this article, we will learn about the entire process of CBD absorption in the body.

What is CBD?

Cannabidiol, also called CBD, is an active phytocannabinoid that is isolated from cannabis plants. It is popular for its anti-inflammatory, pain-relieving, and neuroprotective properties in the body.

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On What Factors Do The Absorption Of CBD Depend?

When a person consumed CBD, it enters systemic circulation in the body. As CBD passes through metabolic processes, it gets transformed in the liver to a broad range of metabolites that finally get expelled via the biliary system.

The metabolism of this natural compound depends on the CBD dose, the channel of administration, as well as bioavailability.

The Endocannabinoid System and Metabolism

The endocannabinoid system helps CBD to interact with the body. This system is linked to energy storage and transference of nutrients that, in turn, regulate mood, inflammation, sleep, and temperature in the body.

The endocannabinoid system is composed of metabolic enzymes that activate several areas of the body. When CBD reaches the body, it interacts with CB1 and CB2 receptors of the ECS system and aid metabolism in the body.

How is CBD Metabolized?

Studies have revealed that CBD gets absorbed by the cytochrome P450 enzyme. This enzyme is present in the liver. To understand how does it get metabolized in the body, we need to look at the different ways to administer it. This is important because the way you consume it plays a significant role in its absorption.

The oral route is the commonest way to consume CBD. Some of the best ways of oral CBD consumption route are pills, edibles, and capsules. After ingestion, CBD gets assimilated by the digestive system, and from there it goes to the liver via the hepatic portal system. The bioavailability of CBD through this route is very low i.e., around 13% to 19%.

The average half-life of CBD post severe oral administration is between 2 to 5 days. This shows that its after-effects can last for a long time. The bioavailability of CBD through inhalation is around 31% and causes instant action in the body. The sublingual method completely bypasses the digestive system and increases the bioavailability of the drug.


Cannabidiol is a potent, natural, and safe remedy to treat a wide range of conditions such as severe pain, insomnia, anxiety, and depression. The understanding of its absorption, formation of metabolites, and its impact on physiological functions is essential to get maximum benefits from it.

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